Gut peptides: Secretion, function and clinical aspects
نویسندگان
چکیده
منابع مشابه
Food-derived bioactive peptides influence gut function.
Bioactive peptides either present in foods or released from food proteins during digestion have a wide range of physiological effects, including on gut function. Many of the bioactive peptides characterized to date that influence gut motility, secretion, and absorption are opioid agonists or antagonists. The authors review a body of experimental evidence that demonstrates an effect of peptides ...
متن کاملGut and adipocyte peptides.
Glucagon-like peptide-1 (and related hormones) Daniel Drucker (Toronto, Canada) reviewed evidence that the incretin effect, the phenomenon of enteral glucose loading increasing the insulin secretory response to an increase in blood glucose, is reduced in type 2 diabetes, and that the incretin glucagon-like peptide (GLP)-1 may ameliorate this defect. The major limitation to use of GLP-1 in clini...
متن کاملBrain and gut peptides.
The first evidence that the same peptides could be present in both the brain and the gut was given in 1931 with the discovery of substance P (Von Euler and Gaddum, 1931). In spite of this early start, the important revelation that there were a large number of peptides with this dual localisation and also with powerful and extensive pharmacological actions took more than 40 years to materialise....
متن کاملSecretion of trophic gut peptides is not different in bolus- and continuously fed piglets.
In neonates, bolus feeding is associated with greater rates of intestinal growth than is continuous feeding. We tested whether the concentrations and secretion rates of trophic gut peptides are higher in bolus-fed than in continuously fed piglets. Five 21-d-old piglets were surgically implanted with gastric, arterial and portal catheters and a portal blood flow probe. At postnatal d 30 and 31, ...
متن کاملGut Peptides Are Novel Regulators of Intestinal Lipoprotein Secretion: Experimental and Pharmacological Manipulation of Lipoprotein Metabolism.
Individuals with metabolic syndrome and frank type 2 diabetes are at increased risk of atherosclerotic cardiovascular disease, partially due to the presence of lipid and lipoprotein abnormalities. In these conditions, the liver and intestine overproduce lipoprotein particles, exacerbating the hyperlipidemia of fasting and postprandial states. Incretin-based, antidiabetes therapies (i.e., glucag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology
سال: 1981
ISSN: 0016-5085
DOI: 10.1016/0016-5085(81)90165-7